tumor heterogeneity

Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues.
Methods for spatially resolved cellular profiling of tissue sections enable in-depth study of inter- and intra-sample heterogeneity but …
André Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Vasco Queiroga, Alicia M Braxton, Ann C Jiang, Kohei Fujikura, Toby C. Cornish, Seung-Mo Hong, Ralph H Hruban, Pei-Hsun Wu, Laura D Wood, Ashley L Kiemen, Denis Wirtz
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3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer for which few effective therapies exist. Immunotherapies specifically …
Ashley L Kiemen, Cristina Almagro-Pérez, Valentina Matos, André Forjaz, Alicia M Braxton, Lucie Dequiedt, Jeeun Parksong, Courtney D Cannon, Xuan Yuan, Sarah M Shin, Jaanvi Mahesh Babu, Elizabeth D Thompson, Toby C. Cornish, Won Jin Ho, Laura D Wood, Pei-Hsun Wu, Arrate Muñoz Barrutia, Ralph H Hruban, Denis Wirtz
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Liver metastases of small intestine neuroendocrine tumors: Ki-67 heterogeneity and World Health Organization grade discordance with primary tumors
OBJECTIVES: We examined Ki-67 heterogeneity within single and between synchronous liver metastases of small intestine neuroendocrine …
Chanjuan Shi, Raul S. Gonzalez, Zhiguo Zhao, Tatsuki Koyama, Toby C. Cornish, Kenneth R. Hande, Ronald Walker, Martin Sandler, Jordan Berlin, Eric H. Liu
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