Tumor

PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison
Purpose: PD-L1 expression in the pretreatment tumor microenvironment enriches for response to anti-PD-1/PD-L1 therapies. The purpose of …
Joel C. Sunshine, Peter L. Nguyen, Genevieve J. Kaunitz, Tricia R. Cottrell, Sneha Berry, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Karen B. Bleich, Toby C. Cornish, Evan J. Lipson, Robert A. Anders, Janis M. Taube
Cite DOI
Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
PURPOSE: To evaluate safety and characterize anticancer efficacy of hepatic hypoxia-activated intra-arterial therapy (HAIAT) with …
Rafael Duran, Sahar Mirpour, Vasily Pekurovsky, Shanmugasundaram Ganapathy-Kanniappan, Cory F. Brayton, Toby C. Cornish, Boris Gorodetski, Juvenal Reyes, Julius Chapiro, Rudiger E. Schernthaner, Constantine Frangakis, MingDe Lin, Jessica D. Sun, Charles P. Hart, Jean-Francois Geschwind
Cite DOI
PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas
Programmed death ligand 1 (PD-L1) expression by tumor-infiltrating lymphocytes (TILs) and tumor cells in breast cancer has been …
Ashley Cimino-Mathews, Elizabeth Thompson, Janis M. Taube, Xiaobu Ye, Yao Lu, Alan Meeker, Haiying Xu, Rajni Sharma, Kristen Lecksell, Toby C. Cornish, Nathan Cuka, Pedram Argani, Leisha A. Emens
Cite DOI
(1)(8)F-DCFBC PET/CT for PSMA-Based Detection and Characterization of Primary Prostate Cancer
UNLABELLED: We previously demonstrated the ability to detect metastatic prostate cancer using …
Steven P. Rowe, Kenneth L. Gage, Sheila F. Faraj, Katarzyna J. Macura, Toby C. Cornish, Nilda Gonzalez-Roibon, Gunes Guner, Enrico Munari, Alan W. Partin, Christian P. Pavlovich, Misop Han, H. Ballentine Carter, Trinity J. Bivalacqua, Amanda Blackford, Daniel Holt, Robert F. Dannals, George J. Netto, Martin A. Lodge, Ronnie C. Mease, Martin G. Pomper, Steve Y. Cho
Cite DOI
Liver metastases of small intestine neuroendocrine tumors: Ki-67 heterogeneity and World Health Organization grade discordance with primary tumors
OBJECTIVES: We examined Ki-67 heterogeneity within single and between synchronous liver metastases of small intestine neuroendocrine …
Chanjuan Shi, Raul S. Gonzalez, Zhiguo Zhao, Tatsuki Koyama, Toby C. Cornish, Kenneth R. Hande, Ronald Walker, Martin Sandler, Jordan Berlin, Eric H. Liu
Cite DOI
Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis
Distinguishing between solid-pseudopapillary neoplasms (SPNs) and pancreatic neuroendocrine tumors (PanNETs) may pose a diagnostic …
Zina Meriden, Chanjuan Shi, Barish H. Edil, Trevor Ellison, Christopher L. Wolfgang, Toby C. Cornish, Richard D. Schulick, Ralph H. Hruban
Cite DOI
Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile
Clear cell change is seen in textless1% of colonic tubular adenomas (TAs) and remains incompletely characterized. Associated …
Chanjuan Shi, Jennifer R. Scudiere, Toby C. Cornish, Dora Lam-Himlin, Jason Y. Park, Michael R. Fox, Elizabeth A. Montgomery
Cite DOI
DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity
Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic epigenetic alterations discovered in human cancers. …
Srinivasan Yegnasubramanian, Michael C. Haffner, Yonggang Zhang, Bora Gurel, Toby C. Cornish, Zhijin Wu, Rafael A. Irizarry, James Morgan, Jessica Hicks, Theodore L. DeWeese, William B. Isaacs, G. Steven Bova, Angelo M. De Marzo, William G. Nelson
Cite DOI
Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
The MYC onco-protein is a transcription factor that regulates cell proliferation, metabolism, protein synthesis, mitochondrial function …
Bora Gurel, Tsuyoshi Iwata, Cheryl M. Koh, Robert B. Jenkins, Fusheng Lan, Chi Van Dang, Jessica L. Hicks, James Morgan, Toby C. Cornish, Siobhan Sutcliffe, William B. Isaacs, Jun Luo, Angelo M. De Marzo
Cite DOI