Tissue Array Analysis

Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues.
Methods for spatially resolved cellular profiling of tissue sections enable in-depth study of inter- and intra-sample heterogeneity but …
André Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Vasco Queiroga, Alicia M Braxton, Ann C Jiang, Kohei Fujikura, Toby C. Cornish, Seung-Mo Hong, Ralph H Hruban, Pei-Hsun Wu, Laura D Wood, Ashley L Kiemen, Denis Wirtz
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Rapid Loss of RNA Detection by In Situ Hybridization in Stored Tissue Blocks and Preservation by Cold Storage of Unstained Slides
Objectives: Recent commercialization of methods for in situ hybridization using Z-pair probe/branched DNA amplification has led to …
Javier A. Baena-Del Valle, Qizhi Zheng, Jessica L. Hicks, Helen Fedor, Bruce J. Trock, Colm Morrissey, Eva Corey, Toby C. Cornish, Karen S. Sfanos, Angelo M. De Marzo
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PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas
Programmed death ligand 1 (PD-L1) expression by tumor-infiltrating lymphocytes (TILs) and tumor cells in breast cancer has been …
Ashley Cimino-Mathews, Elizabeth Thompson, Janis M. Taube, Xiaobu Ye, Yao Lu, Alan Meeker, Haiying Xu, Rajni Sharma, Kristen Lecksell, Toby C. Cornish, Nathan Cuka, Pedram Argani, Leisha A. Emens
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Creation, validation, and quantitative analysis of protein expression in vascular tissue microarrays
BACKGROUND: Tissue microarrays (TMAs) are collections of multiple tissue cores placed in parallel in a single acceptor block and …
Marc K. Halushka, Toby C. Cornish, Jie Lu, Steve Selvin, Elizabeth Selvin
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Glomerular protein levels of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 are lower in diabetic subjects
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) regulate extracellular matrix turnover throughout …
Toby C. Cornish, Serena M. Bagnasco, Anne M. Macgregor, Jie Lu, Elizabeth Selvin, Marc K. Halushka
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Color deconvolution for the analysis of tissue microarrays
OBJECTIVE: To analyze tissue microarrays (TMAs) using color deconvolution, a method for separating component dyes in digital images, …
Toby C. Cornish, Marc K. Halushka
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Color deconvolution for the analysis of tissue microarrays.
To analyze tissue microarrays (TMAs) using color deconvolution, a method for separating component dyes in digital images, and compare …
Toby C. Cornish, Marc K Halushka
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Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
The MYC onco-protein is a transcription factor that regulates cell proliferation, metabolism, protein synthesis, mitochondrial function …
Bora Gurel, Tsuyoshi Iwata, Cheryl M. Koh, Robert B. Jenkins, Fusheng Lan, Chi Van Dang, Jessica L. Hicks, James Morgan, Toby C. Cornish, Siobhan Sutcliffe, William B. Isaacs, Jun Luo, Angelo M. De Marzo
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