Prostatic Neoplasms

Rapid Loss of RNA Detection by In Situ Hybridization in Stored Tissue Blocks and Preservation by Cold Storage of Unstained Slides
Objectives: Recent commercialization of methods for in situ hybridization using Z-pair probe/branched DNA amplification has led to …
Javier A. Baena-Del Valle, Qizhi Zheng, Jessica L. Hicks, Helen Fedor, Bruce J. Trock, Colm Morrissey, Eva Corey, Toby C. Cornish, Karen S. Sfanos, Angelo M. De Marzo
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Low Intratumoral Mast Cells Are Associated With a Higher Risk of Prostate Cancer Recurrence
BACKGROUND: Mast cells are of interest in prostate cancer because they possess both pro- and anti-tumorigenic properties and are …
Heidi A. Hempel, Nathan S. Cuka, Ibrahim Kulac, John R. Barber, Toby C. Cornish, Elizabeth A. Platz, Angelo M. De Marzo, Karen S. Sfanos
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(1)(8)F-DCFBC PET/CT for PSMA-Based Detection and Characterization of Primary Prostate Cancer
UNLABELLED: We previously demonstrated the ability to detect metastatic prostate cancer using …
Steven P. Rowe, Kenneth L. Gage, Sheila F. Faraj, Katarzyna J. Macura, Toby C. Cornish, Nilda Gonzalez-Roibon, Gunes Guner, Enrico Munari, Alan W. Partin, Christian P. Pavlovich, Misop Han, H. Ballentine Carter, Trinity J. Bivalacqua, Amanda Blackford, Daniel Holt, Robert F. Dannals, George J. Netto, Martin A. Lodge, Ronnie C. Mease, Martin G. Pomper, Steve Y. Cho
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High-resolution transrectal ultrasound: pilot study of a novel technique for imaging clinically localized prostate cancer
OBJECTIVES: To determine how high-resolution transrectal ultrasound (HiTRUS) compares with conventional TRUS (LoTRUS) for the …
Christian P. Pavlovich, Toby C. Cornish, Jeffrey K. Mullins, Joel Fradin, Lynda Z. Mettee, Jason T. Connor, Adam C. Reese, Frederic B. Askin, Rachael Luck, Jonathan I. Epstein, Harry B. Burke
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DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity
Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic epigenetic alterations discovered in human cancers. …
Srinivasan Yegnasubramanian, Michael C. Haffner, Yonggang Zhang, Bora Gurel, Toby C. Cornish, Zhijin Wu, Rafael A. Irizarry, James Morgan, Jessica Hicks, Theodore L. DeWeese, William B. Isaacs, G. Steven Bova, Angelo M. De Marzo, William G. Nelson
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Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
The MYC onco-protein is a transcription factor that regulates cell proliferation, metabolism, protein synthesis, mitochondrial function …
Bora Gurel, Tsuyoshi Iwata, Cheryl M. Koh, Robert B. Jenkins, Fusheng Lan, Chi Van Dang, Jessica L. Hicks, James Morgan, Toby C. Cornish, Siobhan Sutcliffe, William B. Isaacs, Jun Luo, Angelo M. De Marzo
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