PanIN

Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings
Pancreatic ductal adenocarcinoma is a rare but lethal cancer. Recent evidence reveals that pancreatic intraepithelial neoplasms …
Ashley L. Kiemen, Pei-Hsun Wu, Alicia M. Braxton, Toby C. Cornish, Ralph H. Hruban, Laura Wood, Denis Wirtz, David Zwicker
Cite DOI URL
Three-dimensional assessments are necessary to determine the true spatial tissue composition of diseased tissues
Methods for partially resolved cellular profiling has enabled in-depth quantitative tissue mapping via thinly cut sections to study …
André Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Alicia M. Braxton, Ann C. Jiang, Kohei Fujikura, Toby C. Cornish, Seung-Mo Hong, Ralph H. Hruban, Pei-Hsun Wu, Laura D. Wood, Ashley L. Kiemen, Denis Wirtz
Cite DOI URL
In situ characterization of the 3D microanatomy of the pancreas and pancreatic cancer at single cell resolution
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer. Accumulating evidence indicates the tumor …
Ashley Kiemen, Alicia M. Braxton, Mia P. Grahn, Kyu Sang Han, Jaanvi Mahesh Babu, Rebecca Reichel, Falone Amoa, Seung-Mo Hong, Toby C. Cornish, Elizabeth D. Thompson, Laura D. Wood, Ralph H. Hruban, Pei-Hsun Wu, Denis Wirtz
Cite DOI URL
Pancreatic Intraepithelial Neoplasia
Pancreatic intraepithelial neoplasias (PanINs) are microscopic lesions of the pancreas. Traditionally viewed as a benign metaplasia of …
Toby C. Cornish, Ralph H. Hruban
Cite DOI