Metastasis

Metastatic progression is associated with dynamic changes in the local microenvironment
Most cancer-associated deaths result from metastasis. However, it remains unknown whether the size, microenvironment or other features …
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
BACKGROUND: Somatic mutations have the potential to encode "non-self" immunogenic antigens. We hypothesized that tumors with …
DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity
Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic epigenetic alterations discovered in human cancers. …