Immunohistochemistry

Quantitative Analysis of Ki67, a Prognostic Biomarker in Gastroenteropancreatic Neuroendocrine Tumors
Ki67 labeling index (LI) is the preferred method of establishing grade for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). There are a number of acceptable methods for calculating the Ki67 LI in GEP-NETs, but application of quantitative image analysis is a promising method to increase accuracy and repeatability. KiNet is a single-stage deep-learning-based detection and classification pipeline for Ki67 LI with performance meeting or exceeding the current state of the art.
May 19, 2022 2:00 PM — 3:00 PM MD Anderson Cancer Center (Virtual)
Toby C. Cornish
Quantitative Analysis of Ki67, a Prognostic Biomarker in Gastroenteropancreatic Neuroendocrine Tumors
Clinical Application of Image Analysis in Pathology
Quantitative biomarkers are key prognostic and predictive factors in the diagnosis and treatment of cancer. In the clinical laboratory, …
Toby C. Cornish
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Clinical Application of Image Analysis in Pathology
Generative Adversarial Domain Adaptation for Nucleus Quantification in Images of Tissue Immunohistochemically Stained for Ki-67.
PURPOSE: We focus on the problem of scarcity of annotated training data for nucleus recognition in Ki-67 immunohistochemistry …
Xuhong Zhang, Toby C. Cornish, Lin Yang, Tellen D. Bennett, Debashis Ghosh, Fuyong Xing
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Pixel-to-Pixel Learning With Weak Supervision for Single-Stage Nucleus Recognition in Ki67 Images
OBJECTIVE: Nucleus recognition is a critical yet challenging step in histopathology image analysis, for example, in Ki67 …
Fuyong Xing, Toby C. Cornish, Tell Bennett, Debashis Ghosh, Lin Yang
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HER2 Status in Gastroesophageal Adenocarcinomas: Correlation Between Immunohistochemistry and Fluorescence In Situ Hybridization Methodologies
Semiquantitative immunohistochemistry (IHC) is commonly used in combination with fluorescence in situ hybridization (FISH) to detect …
Scott A. Robertson, Ashley Cimino-Mathews, Toby C. Cornish
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PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison
Purpose: PD-L1 expression in the pretreatment tumor microenvironment enriches for response to anti-PD-1/PD-L1 therapies. The purpose of …
Joel C. Sunshine, Peter L. Nguyen, Genevieve J. Kaunitz, Tricia R. Cottrell, Sneha Berry, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Karen B. Bleich, Toby C. Cornish, Evan J. Lipson, Robert A. Anders, Janis M. Taube
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Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma: Implications for Immunotherapy
Importance: The programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) pathway play an important …
Elizabeth L. Yanik, Genevieve J. Kaunitz, Tricia R. Cottrell, Farah Succaria, Tracee L. McMiller, Maria L. Ascierto, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Toby C. Cornish, Evan J. Lipson, Suzanne L. Topalian, Eric A. Engels, Janis M. Taube
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PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas
Programmed death ligand 1 (PD-L1) expression by tumor-infiltrating lymphocytes (TILs) and tumor cells in breast cancer has been …
Ashley Cimino-Mathews, Elizabeth Thompson, Janis M. Taube, Xiaobu Ye, Yao Lu, Alan Meeker, Haiying Xu, Rajni Sharma, Kristen Lecksell, Toby C. Cornish, Nathan Cuka, Pedram Argani, Leisha A. Emens
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(1)(8)F-DCFBC PET/CT for PSMA-Based Detection and Characterization of Primary Prostate Cancer
UNLABELLED: We previously demonstrated the ability to detect metastatic prostate cancer using …
Steven P. Rowe, Kenneth L. Gage, Sheila F. Faraj, Katarzyna J. Macura, Toby C. Cornish, Nilda Gonzalez-Roibon, Gunes Guner, Enrico Munari, Alan W. Partin, Christian P. Pavlovich, Misop Han, H. Ballentine Carter, Trinity J. Bivalacqua, Amanda Blackford, Daniel Holt, Robert F. Dannals, George J. Netto, Martin A. Lodge, Ronnie C. Mease, Martin G. Pomper, Steve Y. Cho
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Grading of well-differentiated pancreatic neuroendocrine tumors is improved by the inclusion of both Ki67 proliferative index and mitotic rate.
The grading system for pancreatic neuroendocrine tumors (PanNETs) adopted in 2010 by the World Health Organization (WHO) mandates the …
Chad M. McCall, Chanjuan Shi, Toby C. Cornish, David S. Klimstra, Laura H. Tang, Olca Basturk, Liew Jun Mun, Trevor A. Ellison, Christopher L. Wolfgang, Michael A. Choti, Richard D. Schulick, Barish H. Edil, Ralph H. Hruban
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