Image analysis

Artificial intelligence for automating the measurement of histologic image biomarkers
Artificial intelligence has been applied to histopathology for decades, but the recent increase in interest is attributable to …
Toby C. Cornish
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Artificial intelligence for automating the measurement of histologic image biomarkers
Artificial intelligence for pathology
Advances in artificial intelligence (AI), especially in deep learning, improve pathological image analysis in basic, translational, and …
Fuyong Xing, Xuhong Zhang, Toby C. Cornish
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Clinical Application of Image Analysis in Pathology
Quantitative biomarkers are key prognostic and predictive factors in the diagnosis and treatment of cancer. In the clinical laboratory, …
Toby C. Cornish
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Clinical Application of Image Analysis in Pathology
PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison
Purpose: PD-L1 expression in the pretreatment tumor microenvironment enriches for response to anti-PD-1/PD-L1 therapies. The purpose of …
Joel C. Sunshine, Peter L. Nguyen, Genevieve J. Kaunitz, Tricia R. Cottrell, Sneha Berry, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Karen B. Bleich, Toby C. Cornish, Evan J. Lipson, Robert A. Anders, Janis M. Taube
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Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma: Implications for Immunotherapy
Importance: The programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) pathway play an important …
Elizabeth L. Yanik, Genevieve J. Kaunitz, Tricia R. Cottrell, Farah Succaria, Tracee L. McMiller, Maria L. Ascierto, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Toby C. Cornish, Evan J. Lipson, Suzanne L. Topalian, Eric A. Engels, Janis M. Taube
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Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
PURPOSE: To evaluate safety and characterize anticancer efficacy of hepatic hypoxia-activated intra-arterial therapy (HAIAT) with …
Rafael Duran, Sahar Mirpour, Vasily Pekurovsky, Shanmugasundaram Ganapathy-Kanniappan, Cory F. Brayton, Toby C. Cornish, Boris Gorodetski, Juvenal Reyes, Julius Chapiro, Rudiger E. Schernthaner, Constantine Frangakis, MingDe Lin, Jessica D. Sun, Charles P. Hart, Jean-Francois Geschwind
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Human papillomavirus clearance among males is associated with HIV acquisition and increased dendritic cell density in the foreskin
BACKGROUND: The association between human papillomavirus (HPV) infection and the risk of human immunodeficiency virus (HIV) …
Aaron A. R. Tobian, Mary K. Grabowski, Godfrey Kigozi, Andrew D. Redd, Kevin P. Eaton, David Serwadda, Toby C. Cornish, Fred Nalugoda, Stephen Watya, Denis Buwembo, James Nkale, Maria J. Wawer, Thomas C. Quinn, Ronald H. Gray
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Effects of HIV-1 and herpes simplex virus type 2 infection on lymphocyte and dendritic cell density in adult foreskins from Rakai, Uganda
BACKGROUND: Male circumcision reduces human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV-2) acquisition, and HSV-2 …
Kristine E. Johnson, Andrew D. Redd, Thomas C. Quinn, Aleisha N. Collinson-Streng, Toby C. Cornish, Xiangrong Kong, Rajni Sharma, Aaron A. R. Tobian, Benjamin Tsai, Mark E. Sherman, Godfrey Kigozi, David Serwadda, Maria J. Wawer, Ronald H. Gray
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Creation, validation, and quantitative analysis of protein expression in vascular tissue microarrays
BACKGROUND: Tissue microarrays (TMAs) are collections of multiple tissue cores placed in parallel in a single acceptor block and …
Marc K. Halushka, Toby C. Cornish, Jie Lu, Steve Selvin, Elizabeth Selvin
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Characterization of human mesenchymal stem cell-engineered cartilage: analysis of its ultrastructure, cell density and chondrocyte phenotype compared to native adult and fetal cartilage.
The production of engineered cartilage from mesenchymal stem cells is a rapidly developing field. Potential applications include the …
Alexander T. Hillel, Janis M. Taube, Toby C. Cornish, Blanka Sharma, Marc Halushka, Edward F. McCarthy, Grover M. Hutchins, Jennifer H. Elisseeff
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