Humans

A comprehensive histopathological evaluation of vascular medial fibrosis: insights into the pathophysiology of arterial stiffening
OBJECTIVE: Medial vascular fibrosis contributes to arterial stiffening and reduced compliance, increasing the risk of cardiovascular …
Elizabeth Selvin, Samer S. Najjar, Toby C. Cornish, Marc K. Halushka
Cite DOI
Characterization of human mesenchymal stem cell-engineered cartilage: analysis of its ultrastructure, cell density and chondrocyte phenotype compared to native adult and fetal cartilage.
The production of engineered cartilage from mesenchymal stem cells is a rapidly developing field. Potential applications include the …
Alexander T. Hillel, Janis M. Taube, Toby C. Cornish, Blanka Sharma, Marc Halushka, Edward F. McCarthy, Grover M. Hutchins, Jennifer H. Elisseeff
Cite DOI
Glomerular protein levels of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 are lower in diabetic subjects
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) regulate extracellular matrix turnover throughout …
Toby C. Cornish, Serena M. Bagnasco, Anne M. Macgregor, Jie Lu, Elizabeth Selvin, Marc K. Halushka
Cite DOI
Color deconvolution for the analysis of tissue microarrays
OBJECTIVE: To analyze tissue microarrays (TMAs) using color deconvolution, a method for separating component dyes in digital images, …
Toby C. Cornish, Marc K. Halushka
Cite
Use of human vascular tissue microarrays for measurement of advanced glycation endproducts
Advanced glycation endproducts (AGEs) are present in the vasculature and are associated with vascular disease. We determined levels of …
Marc K. Halushka, Elizabeth Selvin, Jie Lu, Anne M. Macgregor, Toby C. Cornish
Cite DOI
DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity
Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic epigenetic alterations discovered in human cancers. …
Srinivasan Yegnasubramanian, Michael C. Haffner, Yonggang Zhang, Bora Gurel, Toby C. Cornish, Zhijin Wu, Rafael A. Irizarry, James Morgan, Jessica Hicks, Theodore L. DeWeese, William B. Isaacs, G. Steven Bova, Angelo M. De Marzo, William G. Nelson
Cite DOI
Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
The MYC onco-protein is a transcription factor that regulates cell proliferation, metabolism, protein synthesis, mitochondrial function …
Bora Gurel, Tsuyoshi Iwata, Cheryl M. Koh, Robert B. Jenkins, Fusheng Lan, Chi Van Dang, Jessica L. Hicks, James Morgan, Toby C. Cornish, Siobhan Sutcliffe, William B. Isaacs, Jun Luo, Angelo M. De Marzo
Cite DOI