Humans

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
BACKGROUND: Somatic mutations have the potential to encode "non-self" immunogenic antigens. We hypothesized that tumors with …
Dung T. Le, Jennifer N. Uram, Hao Wang, Bjarne R. Bartlett, Holly Kemberling, Aleksandra D. Eyring, Andrew D. Skora, Brandon S. Luber, Nilofer S. Azad, Dan Laheru, Barbara Biedrzycki, Ross C. Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Steven M. Duffy, Richard M. Goldberg, Albert de la Chapelle, Minori Koshiji, Feriyl Bhaijee, Thomas Huebner, Ralph H. Hruban, Laura D. Wood, Nathan Cuka, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Shibin Zhou, Toby C. Cornish, Janis M. Taube, Robert A. Anders, James R. Eshleman, Bert Vogelstein, Luis A. Jr Diaz
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Liver metastases of small intestine neuroendocrine tumors: Ki-67 heterogeneity and World Health Organization grade discordance with primary tumors
OBJECTIVES: We examined Ki-67 heterogeneity within single and between synchronous liver metastases of small intestine neuroendocrine …
Chanjuan Shi, Raul S. Gonzalez, Zhiguo Zhao, Tatsuki Koyama, Toby C. Cornish, Kenneth R. Hande, Ronald Walker, Martin Sandler, Jordan Berlin, Eric H. Liu
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miRge - A Multiplexed Method of Processing Small RNA-Seq Data to Determine MicroRNA Entropy
Small RNA RNA-seq for microRNAs (miRNAs) is a rapidly developing field where opportunities still exist to create better bioinformatics …
Alexander S. Baras, Christopher J. Mitchell, Jason R. Myers, Simone Gupta, Lien-Chun Weng, John M. Ashton, Toby C. Cornish, Akhilesh Pandey, Marc K. Halushka
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Radiologic-pathologic analysis of contrast-enhanced and diffusion- weighted MR imaging in patients with HCC after TACE: diagnostic accuracy of 3D quantitative image analysis
PURPOSE: To evaluate the diagnostic performance of three-dimensional ( 3D three-dimensional ) quantitative enhancement-based and …
Julius Chapiro, Laura D. Wood, MingDe Lin, Rafael Duran, Toby C. Cornish, David Lesage, Vivek Charu, Rudiger Schernthaner, Zhijun Wang, Vania Tacher, Lynn Jeanette Savic, Ihab R. Kamel, Jean-Francois Geschwind
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Lessons from miR-143/145: the importance of cell-type localization of miRNAs
miR-143 and miR-145 are co-expressed microRNAs (miRNAs) that have been extensively studied as potential tumor suppressors. These miRNAs …
Oliver A. Kent, Matthew N. McCall, Toby C. Cornish, Marc K. Halushka
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Fatal spontaneous Clostridium septicum gas gangrene: a possible association with iatrogenic gastric acid suppression.
The long-term use of proton pump inhibitors has been linked to an increased risk for the development of gastric polyps, hip fractures, …
Yiru E. Wu, Alexander Baras, Toby C. Cornish, Stefan Riedel, Elizabeth C. Burton
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A single institution's 26-year experience with nonfunctional pancreatic neuroendocrine tumors: a validation of current staging systems and a new prognostic nomogram.
OBJECTIVE: To validate the 2010 American Joint Committee on Cancer (AJCC) and 2006 European Neuroendocrine Tumor Society (ENETS) tumor …
Trevor A. Ellison, Christopher L. Wolfgang, Chanjuan Shi, John L. Cameron, Peter Murakami, Liew Jun Mun, Aatur D. Singhi, Toby C. Cornish, Kelly Olino, Zina Meriden, Michael Choti, Luis A. Diaz, Timothy M. Pawlik, Richard D. Schulick, Ralph H. Hruban, Barish H. Edil
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A critical evaluation of microRNA biomarkers in non-neoplastic disease
BACKGROUND: MicroRNAs (miRNAs) are small ( approximately 22-nt), stable RNAs that critically modulate post-transcriptional gene …
Baqer A. Haider, Alexander S. Baras, Matthew N. McCall, Joshua A. Hertel, Toby C. Cornish, Marc K. Halushka
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High-resolution transrectal ultrasound: pilot study of a novel technique for imaging clinically localized prostate cancer
OBJECTIVES: To determine how high-resolution transrectal ultrasound (HiTRUS) compares with conventional TRUS (LoTRUS) for the …
Christian P. Pavlovich, Toby C. Cornish, Jeffrey K. Mullins, Joel Fradin, Lynda Z. Mettee, Jason T. Connor, Adam C. Reese, Frederic B. Askin, Rachael Luck, Jonathan I. Epstein, Harry B. Burke
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Grading of well-differentiated pancreatic neuroendocrine tumors is improved by the inclusion of both Ki67 proliferative index and mitotic rate.
The grading system for pancreatic neuroendocrine tumors (PanNETs) adopted in 2010 by the World Health Organization (WHO) mandates the …
Chad M. McCall, Chanjuan Shi, Toby C. Cornish, David S. Klimstra, Laura H. Tang, Olca Basturk, Liew Jun Mun, Trevor A. Ellison, Christopher L. Wolfgang, Michael A. Choti, Richard D. Schulick, Barish H. Edil, Ralph H. Hruban
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