Humans

Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma: Implications for Immunotherapy
Importance: The programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) pathway play an important …
Elizabeth L. Yanik, Genevieve J. Kaunitz, Tricia R. Cottrell, Farah Succaria, Tracee L. McMiller, Maria L. Ascierto, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Toby C. Cornish, Evan J. Lipson, Suzanne L. Topalian, Eric A. Engels, Janis M. Taube
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Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma.
OBJECTIVE: Recent data supports a significant role for immune checkpoint inhibitors in the treatment of solid tumours. Here, we …
Elizabeth D. Thompson, Marianna Zahurak, Adrian Murphy, Toby C. Cornish, Nathan Cuka, Eihab Abdelfatah, Stephen Yang, Mark Duncan, Nita Ahuja, Janis M. Taube, Robert A. Anders, Ronan J. Kelly
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Tough to Swallow: Esophageal Food Impaction from Esophageal Amyloidosis.
Sonali Palchaudhuri, Toby C. Cornish, Casey Inouye, Ashish Nimgaonkar
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Low Intratumoral Mast Cells Are Associated With a Higher Risk of Prostate Cancer Recurrence
BACKGROUND: Mast cells are of interest in prostate cancer because they possess both pro- and anti-tumorigenic properties and are …
Heidi A. Hempel, Nathan S. Cuka, Ibrahim Kulac, John R. Barber, Toby C. Cornish, Elizabeth A. Platz, Angelo M. De Marzo, Karen S. Sfanos
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Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
PURPOSE: To evaluate safety and characterize anticancer efficacy of hepatic hypoxia-activated intra-arterial therapy (HAIAT) with …
Rafael Duran, Sahar Mirpour, Vasily Pekurovsky, Shanmugasundaram Ganapathy-Kanniappan, Cory F. Brayton, Toby C. Cornish, Boris Gorodetski, Juvenal Reyes, Julius Chapiro, Rudiger E. Schernthaner, Constantine Frangakis, MingDe Lin, Jessica D. Sun, Charles P. Hart, Jean-Francois Geschwind
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Metastatic progression is associated with dynamic changes in the local microenvironment
Most cancer-associated deaths result from metastasis. However, it remains unknown whether the size, microenvironment or other features …
Nicole M. Aiello, David L. Bajor, Robert J. Norgard, Amine Sahmoud, Neha Bhagwat, Minh N. Pham, Toby C. Cornish, Christine A. Iacobuzio-Donahue, Robert H. Vonderheide, Ben Z. Stanger
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Genome-wide characterization of human L1 antisense promoter-driven transcripts
BACKGROUND: Long INterspersed Element-1 (LINE-1 or L1) is the only autonomously active, transposable element in the human genome. L1 …
Steven W. Criscione, Nicholas Theodosakis, Goran Micevic, Toby C. Cornish, Kathleen H. Burns, Nicola Neretti, Nemanja Rodic
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Cytomegalovirus Enterocolitis in Immunocompetent Young Children: A Report of Two Cases and Review of the Literature.
Cytomegalovirus (CMV) causes significant morbidity and mortality in congenitally infected children and immunocompromised hosts. Among …
Paul K. Sue, Nicole M. Salazar-Austin, Oliver G. McDonald, Arvind Rishi, Toby C. Cornish, Ravit Arav-Boger
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Utilization of HPASubC for the Identification of Sinusoid-Specific Proteins in the Liver
Mass spectrometry-based proteomes of human organs and tissues are powerful tools but fail to capture protein localization and …
Divine-Favour Anene, Avi Z. Rosenberg, David E. Kleiner, Toby C. Cornish, Marc K. Halushka
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PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas
Programmed death ligand 1 (PD-L1) expression by tumor-infiltrating lymphocytes (TILs) and tumor cells in breast cancer has been …
Ashley Cimino-Mathews, Elizabeth Thompson, Janis M. Taube, Xiaobu Ye, Yao Lu, Alan Meeker, Haiying Xu, Rajni Sharma, Kristen Lecksell, Toby C. Cornish, Nathan Cuka, Pedram Argani, Leisha A. Emens
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