Humans

Clinical Application of Image Analysis in Pathology
Quantitative biomarkers are key prognostic and predictive factors in the diagnosis and treatment of cancer. In the clinical laboratory, …
Toby C. Cornish
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Clinical Application of Image Analysis in Pathology
Generative Adversarial Domain Adaptation for Nucleus Quantification in Images of Tissue Immunohistochemically Stained for Ki-67.
PURPOSE: We focus on the problem of scarcity of annotated training data for nucleus recognition in Ki-67 immunohistochemistry …
Xuhong Zhang, Toby C. Cornish, Lin Yang, Tellen D. Bennett, Debashis Ghosh, Fuyong Xing
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Lifting Agent Granuloma: Histologic Findings Following Use of ORISE Gel for Endoscopic Resections in the Gastrointestinal Tract
OBJECTIVES: Histologic findings after endoscopic resection using submucosal lifting agents Eleview and ORISE gel are described. …
Lindsey M. Westbrook, Patrick A. Henn, Toby C. Cornish
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Pixel-to-Pixel Learning With Weak Supervision for Single-Stage Nucleus Recognition in Ki67 Images
OBJECTIVE: Nucleus recognition is a critical yet challenging step in histopathology image analysis, for example, in Ki67 …
Fuyong Xing, Toby C. Cornish, Tell Bennett, Debashis Ghosh, Lin Yang
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US Food and Drug Administration Approval of Whole Slide Imaging for Primary Diagnosis: A Key Milestone Is Reached and New Questions Are Raised
April 12, 2017 marked a significant day in the evolution of digital pathology in the United States, when the US Food and Drug …
Andrew J. Evans, Thomas W. Bauer, Marilyn M. Bui, Toby C. Cornish, Helena Duncan, Eric F. Glassy, Jason Hipp, Robert S. McGee, Doug Murphy, Charles Myers, Dennis G. O'Neill, Anil v. Parwani, B. Alan Rampy, Mohamed E. Salama, Liron Pantanowitz
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HER2 Status in Gastroesophageal Adenocarcinomas: Correlation Between Immunohistochemistry and Fluorescence In Situ Hybridization Methodologies
Semiquantitative immunohistochemistry (IHC) is commonly used in combination with fluorescence in situ hybridization (FISH) to detect …
Scott A. Robertson, Ashley Cimino-Mathews, Toby C. Cornish
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Rapid Loss of RNA Detection by In Situ Hybridization in Stored Tissue Blocks and Preservation by Cold Storage of Unstained Slides
Objectives: Recent commercialization of methods for in situ hybridization using Z-pair probe/branched DNA amplification has led to …
Javier A. Baena-Del Valle, Qizhi Zheng, Jessica L. Hicks, Helen Fedor, Bruce J. Trock, Colm Morrissey, Eva Corey, Toby C. Cornish, Karen S. Sfanos, Angelo M. De Marzo
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Patient Privacy and Clinical Laboratory Data.
Jason Y. Park, Toby C. Cornish, Michael Hogarth, Brian R. Jackson, Kristen B. Rosati
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PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison
Purpose: PD-L1 expression in the pretreatment tumor microenvironment enriches for response to anti-PD-1/PD-L1 therapies. The purpose of …
Joel C. Sunshine, Peter L. Nguyen, Genevieve J. Kaunitz, Tricia R. Cottrell, Sneha Berry, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Karen B. Bleich, Toby C. Cornish, Evan J. Lipson, Robert A. Anders, Janis M. Taube
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Association of HIV Status With Local Immune Response to Anal Squamous Cell Carcinoma: Implications for Immunotherapy
Importance: The programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) pathway play an important …
Elizabeth L. Yanik, Genevieve J. Kaunitz, Tricia R. Cottrell, Farah Succaria, Tracee L. McMiller, Maria L. Ascierto, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Toby C. Cornish, Evan J. Lipson, Suzanne L. Topalian, Eric A. Engels, Janis M. Taube
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