Biomarkers

Artificial intelligence for automating the measurement of histologic image biomarkers
Artificial intelligence has been applied to histopathology for decades, but the recent increase in interest is attributable to …
Toby C. Cornish
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Artificial intelligence for automating the measurement of histologic image biomarkers
PD-L1 Expression in Melanoma: A Quantitative Immunohistochemical Antibody Comparison
Purpose: PD-L1 expression in the pretreatment tumor microenvironment enriches for response to anti-PD-1/PD-L1 therapies. The purpose of …
Joel C. Sunshine, Peter L. Nguyen, Genevieve J. Kaunitz, Tricia R. Cottrell, Sneha Berry, Jessica Esandrio, Haiying Xu, Aleksandra Ogurtsova, Karen B. Bleich, Toby C. Cornish, Evan J. Lipson, Robert A. Anders, Janis M. Taube
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Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
PURPOSE: To evaluate safety and characterize anticancer efficacy of hepatic hypoxia-activated intra-arterial therapy (HAIAT) with …
Rafael Duran, Sahar Mirpour, Vasily Pekurovsky, Shanmugasundaram Ganapathy-Kanniappan, Cory F. Brayton, Toby C. Cornish, Boris Gorodetski, Juvenal Reyes, Julius Chapiro, Rudiger E. Schernthaner, Constantine Frangakis, MingDe Lin, Jessica D. Sun, Charles P. Hart, Jean-Francois Geschwind
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PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas
Programmed death ligand 1 (PD-L1) expression by tumor-infiltrating lymphocytes (TILs) and tumor cells in breast cancer has been …
Ashley Cimino-Mathews, Elizabeth Thompson, Janis M. Taube, Xiaobu Ye, Yao Lu, Alan Meeker, Haiying Xu, Rajni Sharma, Kristen Lecksell, Toby C. Cornish, Nathan Cuka, Pedram Argani, Leisha A. Emens
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(1)(8)F-DCFBC PET/CT for PSMA-Based Detection and Characterization of Primary Prostate Cancer
UNLABELLED: We previously demonstrated the ability to detect metastatic prostate cancer using …
Steven P. Rowe, Kenneth L. Gage, Sheila F. Faraj, Katarzyna J. Macura, Toby C. Cornish, Nilda Gonzalez-Roibon, Gunes Guner, Enrico Munari, Alan W. Partin, Christian P. Pavlovich, Misop Han, H. Ballentine Carter, Trinity J. Bivalacqua, Amanda Blackford, Daniel Holt, Robert F. Dannals, George J. Netto, Martin A. Lodge, Ronnie C. Mease, Martin G. Pomper, Steve Y. Cho
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Liver metastases of small intestine neuroendocrine tumors: Ki-67 heterogeneity and World Health Organization grade discordance with primary tumors
OBJECTIVES: We examined Ki-67 heterogeneity within single and between synchronous liver metastases of small intestine neuroendocrine …
Chanjuan Shi, Raul S. Gonzalez, Zhiguo Zhao, Tatsuki Koyama, Toby C. Cornish, Kenneth R. Hande, Ronald Walker, Martin Sandler, Jordan Berlin, Eric H. Liu
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A critical evaluation of microRNA biomarkers in non-neoplastic disease
BACKGROUND: MicroRNAs (miRNAs) are small ( approximately 22-nt), stable RNAs that critically modulate post-transcriptional gene …
Baqer A. Haider, Alexander S. Baras, Matthew N. McCall, Joshua A. Hertel, Toby C. Cornish, Marc K. Halushka
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Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis
Distinguishing between solid-pseudopapillary neoplasms (SPNs) and pancreatic neuroendocrine tumors (PanNETs) may pose a diagnostic …
Zina Meriden, Chanjuan Shi, Barish H. Edil, Trevor Ellison, Christopher L. Wolfgang, Toby C. Cornish, Richard D. Schulick, Ralph H. Hruban
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Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile
Clear cell change is seen in textless1% of colonic tubular adenomas (TAs) and remains incompletely characterized. Associated …
Chanjuan Shi, Jennifer R. Scudiere, Toby C. Cornish, Dora Lam-Himlin, Jason Y. Park, Michael R. Fox, Elizabeth A. Montgomery
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Color deconvolution for the analysis of tissue microarrays
OBJECTIVE: To analyze tissue microarrays (TMAs) using color deconvolution, a method for separating component dyes in digital images, …
Toby C. Cornish, Marc K. Halushka
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