Animals

Rapid Loss of RNA Detection by In Situ Hybridization in Stored Tissue Blocks and Preservation by Cold Storage of Unstained Slides
Objectives: Recent commercialization of methods for in situ hybridization using Z-pair probe/branched DNA amplification has led to …
Javier A. Baena-Del Valle, Qizhi Zheng, Jessica L. Hicks, Helen Fedor, Bruce J. Trock, Colm Morrissey, Eva Corey, Toby C. Cornish, Karen S. Sfanos, Angelo M. De Marzo
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Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer
PURPOSE: To evaluate safety and characterize anticancer efficacy of hepatic hypoxia-activated intra-arterial therapy (HAIAT) with …
Rafael Duran, Sahar Mirpour, Vasily Pekurovsky, Shanmugasundaram Ganapathy-Kanniappan, Cory F. Brayton, Toby C. Cornish, Boris Gorodetski, Juvenal Reyes, Julius Chapiro, Rudiger E. Schernthaner, Constantine Frangakis, MingDe Lin, Jessica D. Sun, Charles P. Hart, Jean-Francois Geschwind
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Metastatic progression is associated with dynamic changes in the local microenvironment
Most cancer-associated deaths result from metastasis. However, it remains unknown whether the size, microenvironment or other features …
Nicole M. Aiello, David L. Bajor, Robert J. Norgard, Amine Sahmoud, Neha Bhagwat, Minh N. Pham, Toby C. Cornish, Christine A. Iacobuzio-Donahue, Robert H. Vonderheide, Ben Z. Stanger
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Genome-wide characterization of human L1 antisense promoter-driven transcripts
BACKGROUND: Long INterspersed Element-1 (LINE-1 or L1) is the only autonomously active, transposable element in the human genome. L1 …
Steven W. Criscione, Nicholas Theodosakis, Goran Micevic, Toby C. Cornish, Kathleen H. Burns, Nicola Neretti, Nemanja Rodic
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miRge - A Multiplexed Method of Processing Small RNA-Seq Data to Determine MicroRNA Entropy
Small RNA RNA-seq for microRNAs (miRNAs) is a rapidly developing field where opportunities still exist to create better bioinformatics …
Alexander S. Baras, Christopher J. Mitchell, Jason R. Myers, Simone Gupta, Lien-Chun Weng, John M. Ashton, Toby C. Cornish, Akhilesh Pandey, Marc K. Halushka
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Yes-associated protein regulates the hepatic response after bile duct ligation
UNLABELLED: Human chronic cholestatic liver diseases are characterized by cholangiocyte proliferation, hepatocyte injury, and fibrosis. …
Haibo Bai, Nailing Zhang, Yang Xu, Qian Chen, Mehtab Khan, James J. Potter, Suresh K. Nayar, Toby C. Cornish, Gianfranco Alpini, Steven Bronk, Duojia Pan, Robert A. Anders
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A polymeric nanoparticle formulation of curcumin (NanoCurc) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro- inflammatory cytokines and stellate cell activation
Plant-derived polyphenols such as curcumin hold promise as a therapeutic agent in the treatment of chronic liver diseases. However, its …
Savita Bisht, Mehtab A. Khan, Mena Bekhit, Haibo Bai, Toby C. Cornish, Masamichi Mizuma, Michelle A. Rudek, Ming Zhao, Amarnath Maitra, Balmiki Ray, Debomoy Lahiri, Anirban Maitra, Robert A. Anders
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Microcontact printing: a versatile technique for the study of synaptogenic molecules
During synaptogenesis information exchanged locally between synaptic partners results in precise alignment of morphological and …
Toby C. Cornish, Darren W. Branch, Bruce C. Wheeler, James T. Campanelli
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Globular domains of agrin are functional units that collaborate to induce acetylcholine receptor clustering
Agrin, an extracellular matrix protein involved in neuromuscular junction formation, directs clustering of postsynaptic molecules, …
Toby C. Cornish, Jamin Chi, Steve Johnson, Yang Lu, James T. Campanelli
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Immunotoxicology of cigarette smoke condensates: suppression of macrophage responsiveness to interferon gamma
We have investigated systematically the effects of short-term exposure to main stream cigarette smoke condensates (CSC-MS) on basal and …
K. M. Braun, Toby C. Cornish, A. Valm, J. Cundiff, J. L. Pauly, S. Fan
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