Adenocarcinoma

HER2 Status in Gastroesophageal Adenocarcinomas: Correlation Between Immunohistochemistry and Fluorescence In Situ Hybridization Methodologies
Semiquantitative immunohistochemistry (IHC) is commonly used in combination with fluorescence in situ hybridization (FISH) to detect …
Scott A. Robertson, Ashley Cimino-Mathews, Toby C. Cornish
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Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma.
OBJECTIVE: Recent data supports a significant role for immune checkpoint inhibitors in the treatment of solid tumours. Here, we …
Elizabeth D. Thompson, Marianna Zahurak, Adrian Murphy, Toby C. Cornish, Nathan Cuka, Eihab Abdelfatah, Stephen Yang, Mark Duncan, Nita Ahuja, Janis M. Taube, Robert A. Anders, Ronan J. Kelly
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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
BACKGROUND: Somatic mutations have the potential to encode "non-self" immunogenic antigens. We hypothesized that tumors with …
Dung T. Le, Jennifer N. Uram, Hao Wang, Bjarne R. Bartlett, Holly Kemberling, Aleksandra D. Eyring, Andrew D. Skora, Brandon S. Luber, Nilofer S. Azad, Dan Laheru, Barbara Biedrzycki, Ross C. Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Steven M. Duffy, Richard M. Goldberg, Albert De La Chapelle, Minori Koshiji, Feriyl Bhaijee, Thomas Huebner, Ralph H. Hruban, Laura D. Wood, Nathan Cuka, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Shibin Zhou, Toby C. Cornish, Janis M. Taube, Robert A. Anders, James R. Eshleman, Bert Vogelstein, Luis A. Jr Diaz
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Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile
Clear cell change is seen in textless1% of colonic tubular adenomas (TAs) and remains incompletely characterized. Associated …
Chanjuan Shi, Jennifer R. Scudiere, Toby C. Cornish, Dora Lam-Himlin, Jason Y. Park, Michael R. Fox, Elizabeth A. Montgomery
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Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
The MYC onco-protein is a transcription factor that regulates cell proliferation, metabolism, protein synthesis, mitochondrial function …
Bora Gurel, Tsuyoshi Iwata, Cheryl M. Koh, Robert B. Jenkins, Fusheng Lan, Chi Van Dang, Jessica L. Hicks, James Morgan, Toby C. Cornish, Siobhan Sutcliffe, William B. Isaacs, Jun Luo, Angelo M. De Marzo
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