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Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues.
Methods for spatially resolved cellular profiling of tissue sections enable in-depth study of inter- and intra-sample heterogeneity but …
André Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Vasco Queiroga, Alicia M Braxton, Ann C Jiang, Kohei Fujikura, Toby C. Cornish, Seung-Mo Hong, Ralph H Hruban, Pei-Hsun Wu, Laura D Wood, Ashley L Kiemen, Denis Wirtz
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PanIN or IPMN? Redefining Lesion Size in 3 Dimensions
Pancreatic ductal adenocarcinoma (PDAC) develops from 2 known precursor lesions: a majority (∼85%) develops from pancreatic …
Ashley L. Kiemen, Lucie Dequiedt, Yu Shen, Yutong Zhu, Valentina Matos Romero, André Forjaz, Kurtis Campbell, Will Dhana, Toby C. Cornish, Alicia M. Braxton, Pei-Hsun Wu, Elliot K. Fishman, Laura D. Wood, Denis Wirtz, Ralph H. Hruban
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Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings
Pancreatic ductal adenocarcinoma is a rare but lethal cancer. Recent evidence suggests that pancreatic intraepithelial neoplasia …
Ashley L. Kiemen, Pei-Hsun Wu, Alicia M. Braxton, Toby C. Cornish, Ralph H. Hruban, Laura D. Wood, Denis Wirtz, David Zwicker
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3D genomic mapping reveals multifocality of human pancreatic precancers
Pancreatic intraepithelial neoplasias (PanINs) are the most common precursors of pancreatic cancer, but their small size and …
Alicia M. Braxton, Ashley L. Kiemen, Mia P. Grahn, André Forjaz, Jeeun Parksong, Jaanvi Mahesh Babu, Jiaying Lai, Lily Zheng, Noushin Niknafs, Liping Jiang, Haixia Cheng, Qianqian Song, Rebecca Reichel, Sarah Graham, Alexander I. Damanakis, Catherine G. Fischer, Stephanie Mou, Cameron Metz, Julie Granger, Xiao-Ding Liu, Niklas Bachmann, Yutong Zhu, YunZhou Liu, Cristina Almagro-Pérez, Ann Chenyu Jiang, Jeonghyun Yoo, Bridgette Kim, Scott Du, Eli Foster, Jocelyn Y. Hsu, Paula Andreu Rivera, Linda C. Chu, Fengze Liu, Elliot K. Fishman, Alan Yuille, Nicholas J. Roberts, Elizabeth D. Thompson, Robert B. Scharpf, Toby C. Cornish, Yuchen Jiao, Rachel Karchin, Ralph H. Hruban, Pei-Hsun Wu, Denis Wirtz, Laura D. Wood
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3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer for which few effective therapies exist. Immunotherapies specifically …
Ashley L Kiemen, Cristina Almagro-Pérez, Valentina Matos, André Forjaz, Alicia M Braxton, Lucie Dequiedt, Jeeun Parksong, Courtney D Cannon, Xuan Yuan, Sarah M Shin, Jaanvi Mahesh Babu, Elizabeth D Thompson, Toby C. Cornish, Won Jin Ho, Laura D Wood, Pei-Hsun Wu, Arrate Muñoz Barrutia, Ralph H Hruban, Denis Wirtz
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Learning with limited target data to detect cells in cross-modality images
Deep neural networks have achieved excellent cell or nucleus quantification performance in microscopy images, but they often suffer …
Fuyong Xing, Xinyi Yang, Toby C. Cornish, Debashis Ghosh
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Cybersecurity and Information Assurance for the Clinical Laboratory
BACKGROUND: Network-connected medical devices have rapidly proliferated in the wake of recent global catalysts, leaving clinical …
Ankush U. Patel, Christopher L. Williams, Steven N. Hart, Christopher A. Garcia, Thomas J. S. Durant, Toby C. Cornish, David S. McClintock
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Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions
Pancreatic intraepithelial neoplasia (PanIN) is a precursor to pancreatic cancer and represents a critical opportunity for cancer …
Alicia M. Braxton, Ashley L. Kiemen, Mia P. Grahn, André Forjaz, Jaanvi Mahesh Babu, Lily Zheng, Liping Jiang, Haixia Cheng, Qianqian Song, Rebecca Reichel, Sarah Graham, Alexander I. Damanakis, Catherine G. Fischer, Stephanie Mou, Cameron Metz, Julie Granger, Xiao-Ding Liu, Niklas Bachmann, Cristina Almagro-Pérez, Ann Chenyu Jiang, Jeonghyun Yoo, Bridgette Kim, Scott Du, Eli Foster, Jocelyn Y. Hsu, Paula Andreu Rivera, Linda C. Chu, Fengze Liu, Noushin Niknafs, Elliot K. Fishman, Alan Yuille, Nicholas J. Roberts, Elizabeth D. Thompson, Robert B. Scharpf, Toby C. Cornish, Yuchen Jiao, Rachel Karchin, Ralph H. Hruban, Pei-Hsun Wu, Denis Wirtz, Laura D. Wood
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CODA: quantitative 3D reconstruction of large tissues at cellular resolution
A central challenge in biology is obtaining high-content, high-resolution information while analyzing tissue samples at volumes …
Ashley L. Kiemen, Alicia M. Braxton, Mia P. Grahn, Kyu Sang Han, Jaanvi Mahesh Babu, Rebecca Reichel, Ann C. Jiang, Bridgette Kim, Jocelyn Hsu, Falone Amoa, Sashank Reddy, Seung-Mo Hong, Toby C. Cornish, Elizabeth D. Thompson, Peng Huang, Laura D. Wood, Ralph H. Hruban, Denis Wirtz, Pei-Hsun Wu
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Tissue Displacement Versus Two Primary Colorectal Carcinomas? A Case Report on the Utility of Comparative Sequencing
Ellie S. Hong, Wells A. Messersmith, Hazem Hammad, Toby C. Cornish, Dara L. Aisner
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